Automated cleaning and pre-processing of immunoglobulin gene sequences from high-throughput sequencing

High throughput sequencing (HTS) yields tens of thousands to millions of sequences that require a large amount of pre-processing work to clean various artifacts. Such cleaning cannot be performed manually. Existing programs are not suitable for immunoglobulin (Ig) genes, which are variable and often...

Полное описание

Библиографические подробности

Главные авторы:	Miri eMichaeli, Hila eNoga, Hilla eTabibian-Keissar, Iris eBarshack, Ramit eMehr
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2012-12-01
Серии:	Frontiers in Immunology
Предметы:	high-throughput sequencing B cell receptor Computer programs Immunoglobulin (Ig) genes insertions and deletions (indels).
Online-ссылка:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00386/full
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