Single administration of p2TA (AB103), a CD28 antagonist peptide, prevents inflammatory and thrombotic reactions and protects against gastrointestinal injury in total-body irradiated mice.

The goal of this study was to elucidate the action of the CD28 mimetic peptide p2TA (AB103) that attenuates an excessive inflammatory response in mitigating radiation-induced inflammatory injuries. BALB/c and A/J mice were divided into four groups: Control (C), Peptide (P; 5 mg/kg of p2TA peptide),...

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Autores principales:	Salida Mirzoeva, Tatjana Paunesku, M Beau Wanzer, Anat Shirvan, Raymond Kaempfer, Gayle E Woloschak, William Small
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2014-01-01
Colección:	PLoS ONE
Acceso en línea:	http://europepmc.org/articles/PMC4108308?pdf=render
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