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Impaired dopamine metabolism in Parkinson’s disease pathogenesis

Abstract A full understanding of Parkinson’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A multiple-hit hypothesis has been proposed, which may explain the convergence of familial, environmental and i...

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Principais autores: Anna Masato, Nicoletta Plotegher, Daniela Boassa, Luigi Bubacco
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-08-01
Serier:Molecular Neurodegeneration
Fag:
Parkinson’s disease
Selective vulnerability
Dopamine
DOPAL
αSynuclein
Aldehyde dehydrogenase
Online adgang:http://link.springer.com/article/10.1186/s13024-019-0332-6
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