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Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas

Abstract Background Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermethylation in HPV(+) oropharyngeal cancers, but only few consistent target...

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Principais autores: Davide Degli Esposti, Athena Sklias, Sheila C. Lima, Stéphanie Beghelli-de la Forest Divonne, Vincent Cahais, Nora Fernandez-Jimenez, Marie-Pierre Cros, Szilvia Ecsedi, Cyrille Cuenin, Liacine Bouaoun, Graham Byrnes, Rosita Accardi, Anne Sudaka, Valérie Giordanengo, Hector Hernandez-Vargas, Luis Felipe Ribeiro Pinto, Ellen Van Obberghen-Schilling, Zdenko Herceg
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2017-04-01
Serier:Genome Medicine
Fag:
Head and neck squamous cell carcinomas
HPV
Differentially methylated regions
CpG shores
Predictive models
Online adgang:http://link.springer.com/article/10.1186/s13073-017-0419-z
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