Measuring error rates in genomic perturbation screens: gold standards for human functional genomics

Abstract Technological advancement has opened the door to systematic genetics in mammalian cells. Genome‐scale loss‐of‐function screens can assay fitness defects induced by partial gene knockdown, using RNA interference, or complete gene knockout, using new CRISPR techniques. These screens can revea...

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Detalhes bibliográficos

Principais autores:	Traver Hart, Kevin R Brown, Fabrice Sircoulomb, Robert Rottapel, Jason Moffat
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2014-07-01
coleção:	Molecular Systems Biology
Assuntos:	cancer CRISPR essential genes RNAi shRNA
Acesso em linha:	https://doi.org/10.15252/msb.20145216
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