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Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The risk of developing MS is strongly influenced by genetic predisposition, and over 100 loci have been established as associated with susceptibility. However, the biologically relevant variants un...

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Principais autores: Michele D Binder, Andrew D Fox, Daniel Merlo, Laura J Johnson, Lauren Giuffrida, Sarah E Calvert, Rainer Akkermann, Gerry Z M Ma, ANZgene, Ashwyn A Perera, Melissa M Gresle, Louise Laverick, Grace Foo, Marzena J Fabis-Pedrini, Timothy Spelman, Margaret A Jordan, Alan G Baxter, Simon Foote, Helmut Butzkueven, Trevor J Kilpatrick, Judith Field
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2016-03-01
coleção:PLoS Genetics
Acesso em linha:http://europepmc.org/articles/PMC4798184?pdf=render
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