Clonal diversity shapes the tumour microenvironment leading to distinct immunotherapy responses in metastatic urothelial carcinoma

Abstract Repeated oncogenic mutations and polyclonal proliferation are evident in cancers. However, little is known about the polyclonal principles governing the systemic cancerous lineage during immunotherapy. Here, we examine a unique autopsy case of metastatic urothelial carcinoma that exhibits d...

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Hlavní autoři:	Takashi Kamatani, Kota Umeda, Tomohiro Iwasawa, Fuyuki Miya, Kazuhiro Matsumoto, Shuji Mikami, Kensuke Hara, Masayuki Shimoda, Yutaka Suzuki, Jo Nishino, Mamoru Kato, Kazuhiro Kakimi, Nobuyuki Tanaka, Mototsugu Oya, Tatsuhiko Tsunoda
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-08-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-025-63309-1
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