Structural insight into the unique conformation of cystathionine β-synthase from Toxoplasma gondii

Cysteine plays a major role in the redox homeostasis and antioxidative defense mechanisms of many parasites of the phylum Apicomplexa. Of relevance to human health is Toxoplasma gondii, the causative agent of toxoplasmosis. A major route of cysteine biosynthesis in this parasite is the reverse trans...

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Detalhes bibliográficos

Principais autores:	Carmen Fernández-Rodríguez, Iker Oyenarte, Carolina Conter, Irene González-Recio, Reyes Núñez-Franco, Claudia Gil-Pitarch, Iban Quintana, Gonzalo Jiménez-Osés, Paola Dominici, Maria Luz Martinez-Chantar, Alessandra Astegno, Luis Alfonso Martínez-Cruz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Association for the Advancement of Science (AAAS) 2021-01-01
coleção:	Computational and Structural Biotechnology Journal
Assuntos:	Toxoplasmosis Toxoplasma gondii Reverse transsulfuration Cystathionine β-synthase Hydrogen sulfide Homocysteine
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2001037021002403
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