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Studying Huntington’s Disease in Yeast: From Mechanisms to Pharmacological Approaches

Huntington’s disease (HD) is a neurodegenerative disorder that leads to progressive neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD remains incurable, and available drugs are effective only for symptomatic management. HD is caused by a mutant form of the...

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Principais autores: Sebastian Hofer, Katharina Kainz, Andreas Zimmermann, Maria A. Bauer, Tobias Pendl, Michael Poglitsch, Frank Madeo, Didac Carmona-Gutierrez
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-09-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
Chorea Huntington
huntingtin
drug discovery
disease model
neurodegeneration
apoptosis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fnmol.2018.00318/full
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