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Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients

Neurofibromatosis type 1 (NF1) patients have an 8–13% lifetime risk of developing malignant peripheral nerve sheath tumors (MPNST) which have a very poor prognosis. In this study, cells from eight MPNSTs (six primary and two recurrences) of six clinically and genetically well-characterized NF1 patie...

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Principais autores: Silke Frahm, Victor-F Mautner, Hilde Brems, Eric Legius, Maria Debiec-Rychter, Reinhard E Friedrich, Wolfram T Knöfel, Matthias Peiper, Lan Kluwe
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2004-06-01
coleção:Neurobiology of Disease
Assuntos:
NF1
MPNST
PNF
LOH
Schwann cells
S100
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996104000166
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