Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells

Summary: Renal cell carcinoma (RCC) represents about 90% of kidney cancers, with 30%–40% of patients developing metastatic disease despite current treatments. Conventional chimeric antigen receptor (CAR)-T therapy targeting CD70 shows promise but faces challenges due to its autologous, personalized...

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Hauptverfasser:	Yan-Ruide Li, Junhui Hu, Zhe Li, Enbo Zhu, Yuning Chen, Tyler Halladay, Xinyuan Shen, Ying Fang, Yichen Zhu, Zibai Lyu, Yanxin Tian, Jie Huang, Annabel S. Zhao, Nathan Y. Ma, Catherine Zhang, Yongpeng Xie, Hanwei Zhang, Tzung Hsiai, Arnold I. Chin, Lily Wu, Lili Yang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-09-01
Schriftenreihe:	Cell Reports Medicine
Schlagworte:	Renal cell carcinoma RCC CD70 invariant natural killer T cell NKT cell CAR-NKT cell
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2666379125003945
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