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PFOS-mediated suppression of SOX30 impairs DNA double-strand break repair leading to male reproductive dysfunction

Perfluorooctanesulfonic acid (PFOS), a persistent organic pollutant and representative per- and polyfluoroalkyl substance (PFAS), is ubiquitously detected in the environment and human tissues, and mounting evidence has implicated it in male reproductive dysfunction. However, the direct impact of PFO...

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Main Authors: Kangle Liu, Shijun He, Yuhan Hu, Yaxin Liu, Lei Zhu, Wenfeng Zhang, Xiao Jiang, Jing Gu, Lulu Guo, Zhonghao Zhang, Qing Chen, Lei Sun, Jia Cao, Lin Ao, Jinyi Liu
Format: Artigo
Language:Inglês
Published: Elsevier 2026-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PFOS
Spermatogenesis
Meiosis
Homologous recombination
SOX30
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651326004100
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