Displacement of Native FXYD Protein From Na+/K+-ATPase With Novel FXYD Peptide Derivatives: Effects on Doxorubicin Cytotoxicity

The seven mammalian FXYD proteins associate closely with α/β heterodimers of Na+/K+-ATPase. Most of them protect the β1 subunit against glutathionylation, an oxidative modification that destabilizes the heterodimer and inhibits Na+/K+-ATPase activity. A specific cysteine (Cys) residue of FXYD protei...

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Principais autores:	Chia-Chi Liu, Yeon Jae Kim, Rachel Teh, Alvaro Garcia, Elisha J. Hamilton, Flemming Cornelius, Robert C. Baxter, Helge H. Rasmussen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-03-01
coleção:	Frontiers in Oncology
Assuntos:	breast cancer pancreatic cancer peptide therapy membrane transport oxidative stress dysadherin
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2022.859216/full
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