Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

Innate immunity is critical in the early containment of influenza A virus (IAV) infection and surfactant protein D (SP-D) plays a crucial role in innate defense against IAV in the lungs. Multivalent lectin-mediated interactions of SP-D with IAVs result in viral aggregation, reduced epithelial infect...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Martin van Eijk, Marine L. B. Hillaire, Guus F. Rimmelzwaan, Michael J. Rynkiewicz, Mitchell R. White, Kevan L. Hartshorn, Martin Hessing, Peter A. Koolmees, Monique H. Tersteeg, Maarten H. van Es, Tjarko Meijerhof, Anke Huckriede, Henk P. Haagsman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-10-01
coleção:	Frontiers in Immunology
Assuntos:	antiviral agent influenza A virus innate immunity surfactant protein D collectin pandemics
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02476/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!