Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.

The anti-invasive and anti-proliferative effects of betulins and abietane derivatives was systematically tested using an organotypic model system of advanced, castration-resistant prostate cancers. A preliminary screen of the initial set of 93 compounds was performed in two-dimensional (2D) growth c...

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Bibliografische Detailangaben

Hauptverfasser:	Ville Härmä, Raisa Haavikko, Johannes Virtanen, Ilmari Ahonen, Hannu-Pekka Schukov, Sami Alakurtti, Enkhee Purev, Heiko Rischer, Jari Yli-Kauhaluoma, Vânia M Moreira, Matthias Nees, Kirsi-Marja Oksman-Caldentey
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2015-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://doi.org/10.1371/journal.pone.0126111
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