Intracellular calcium release through IP3R or RyR contributes to secondary axonal degeneration

Severed CNS axons often retract or dieback away from the injury site and fail to regenerate. The precise mechanisms underlying acute axonal dieback and secondary axonal degeneration remain poorly understood. Here we investigate the role of Ca2+ store mediated intra-axonal Ca2+ release in acute axona...

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Principais autores:	Ben C. Orem, Nicolas Pelisch, Joshua Williams, Jacqueline M. Nally, David P. Stirling
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2017-10-01
coleção:	Neurobiology of Disease
Assuntos:	Axonal retraction Ryanodine receptor IP3 receptor Spinal cord injury Two-photon excitation microscopy Axonal dieback
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S096999611730164X
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