Defective EMC1 drives abnormal retinal angiogenesis via Wnt/β-catenin signaling and may be associated with the pathogenesis of familial exudative vitreoretinopathy

Endoplasmic reticulum (ER) membrane protein complex (EMC) is required for the co-translational insertion of newly synthesized multi-transmembrane proteins. Compromised EMC function in different cell types has been implicated in multiple diseases. Using inducible genetic mouse models, we revealed def...

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Auteurs principaux:	Shujin Li, Mu Yang, Rulian Zhao, Li Peng, Wenjing Liu, Xiaoyan Jiang, Yunqi He, Erkuan Dai, Lin Zhang, Yeming Yang, Yi Shi, Peiquan Zhao, Zhenglin Yang, Xianjun Zhu
Format:	Artigo
Langue:	Inglês
Publié:	KeAi Communications Co., Ltd. 2023-11-01
Collection:	Genes and Diseases
Sujets:	Angiogenesis β-catenin signaling EMC1 Familial exudative vitreoretinopathy LiCl
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2352304222002653
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