A prospective, open-label, randomized, crossover study to compare the pharmacokinetics of crushed methotrexate with that of the tablet formulation in patients with head-and-neck cancer

Background: Crushing solid dosage forms is often required in patients with swallowing difficulties; however, the pharmacokinetic (PK) impact of this alteration is not well-studied. Objective: The primary objective was to compare the PK of crushed methotrexate tablets suspended in water versus whole...

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Бібліографічні деталі

Автори:	Manjunath N Krishnamurthy, Vijay Patil, Aditi Shirsat, Sakshi Wairagade, Anupama Pradosh, Sharath Kumar, Shraddha Jadhav, Ashish Chavan, Anand Patil, Amit Joshi, Kumar Prabhash, Vikram Gota, Vanita Noronha
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wolters Kluwer Medknow Publications 2026-01-01
Серія:	Cancer Research, Statistics, and Treatment
Предмети:	bioequivalence crushing crushed tablets methotrexate pharmacokinetics whole tablets
Онлайн доступ:	https://journals.lww.com/crst/fulltext/2026/01000/a_prospective,_open_label,_randomized,_crossover.1.aspx
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