Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions containing siRNA. Current formulation procedures employ m...

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Bibliografske podrobnosti

Principais autores:	Nathan M Belliveau, Jens Huft, Paulo JC Lin, Sam Chen, Alex KK Leung, Timothy J Leaver, Andre W Wild, Justin B Lee, Robert J Taylor, Ying K Tam, Carl L Hansen, Pieter R Cullis
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2012-01-01
Serija:	Molecular Therapy: Nucleic Acids
Teme:	lipid nanoparticle microfluidics nanomedicine siRNA synthesis and formulation
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2162253116300932
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