Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA Synthesis

ABSTRACT Host restriction limits the emergence of novel pandemic strains from the influenza A virus avian reservoir. For efficient replication in mammalian cells, the avian influenza RNA-dependent RNA polymerase must adapt to use human orthologues of the host factor ANP32, which lack a 33-amino-acid...

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Principais autores:	Olivia C. Swann, Amalie B. Rasmussen, Thomas P. Peacock, Carol M. Sheppard, Wendy S. Barclay
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology 2023-02-01
叢編:	mBio
主題:	ANP32A ANP32B RNA polymerases avian viruses influenza viral replication
在線閱讀:	https://journals.asm.org/doi/10.1128/mbio.03399-22
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