Chemically modified CRISPR-Cas9 enables targeting of individual G-quadruplex and i-motif structures, revealing ligand-dependent transcriptional perturbation

Abstract The development of selective ligands to target DNA G-quadruplexes (G4s) and i-motifs (iMs) has revealed their relevance in transcriptional regulation. However, most of these ligands are unable to target individual G4s or iMs in the genome, limiting their scope. Herein, we describe an Approa...

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Detalhes bibliográficos

Principais autores:	Sabrina Pia Nuccio, Enrico Cadoni, Roxani Nikoloudaki, Silvia Galli, An-Jie Ler, Claudia Sanchez-Cabanillas, Thomas E. Maher, Ella Fan, Dilek Guneri, Gem Flint, Minghui Zhu, Ling Sum Liu, Christopher R. Fullenkamp, Zoë Waller, Luca Magnani, John S. Schneekloth, Marco Di Antonio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-12-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-67074-z
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