Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations

Acetylcholinesterase (AChE) inhibitors and calcium channel blockers are considered effective therapies for Alzheimer’s disease. AChE plays an essential role in the nervous system by catalyzing the hydrolysis of the neurotransmitter acetylcholine. In this study, the inhibition of the enzyme AChE by S...

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Autori principali:	Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A. Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Haq
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2022-05-01
Serie:	Molecules
Soggetti:	acetylcholinesterase butyrylcholinesterase steroidal alkaloids inhibition kinetics molecular dynamics simulation ligand-protein docking
Accesso online:	https://www.mdpi.com/1420-3049/27/11/3361
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