Haplotype association between haptoglobin (Hp2) and Hp promoter SNP (A-61C) may explain previous controversy of haptoglobin and malaria protection.

<h4>Background</h4>Malaria is one of the strongest recent selective pressures on the human genome, as evidenced by the high levels of varying haemoglobinopathies in human populations-despite the increased risk of mortality in the homozygous states. Previously, functional polymorphisms of Hp, coded b...

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Hauptverfasser:	Sharon E Cox, Conor Doherty, Sarah H Atkinson, Chidi V Nweneka, Anthony J C Fulford, Hala Ghattas, Kirk A Rockett, Dominic P Kwiatkowski, Andrew M Prentice
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2007-04-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000362&type=printable
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