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Cerebrospinal fluid α-synuclein seed amplification assay positivity is associated with increased plasma neurofilament light chain in Alzheimer's disease

Background: Synucleinopathy is the most common co-pathology in Alzheimer's disease (AD) and can be detected in vivo using cerebrospinal fluid (CSF) alpha-synuclein seed amplification assays (synSAA). CSF synSAA positivity has been linked to worse clinical outcome. This study investigated whether syn...

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Principais autores: Giovanni Bellomo, PhD, Andrea Toja, MD, Lorenzo Gaetani, MD, PhD, Giovanna Nardi, MD, Federico Paolini Paoletti, MD, PhD, Davide Chiasserini, PhD, Lucilla Parnetti, MD, PhD
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-01-01
Serier:Neurobiology of Disease
Fag:
synSAA
NfL
AD
Synucleinopathy
Co-pathology
Neurodegeneration
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996125004516
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