The OGG1 Ser326Cys polymorphism: molecular mechanisms of disease susceptibility and precision medicine applications
Abstract DNA molecules are susceptible to reactive oxygen species (ROS) attack leading to oxidative damage, of which 8-oxoguanine (8-oxoG) is a core oxidative marker. OGG1 acts as a DNA repair enzyme and maintains genomic stability by specifically repairing 8-oxoG through the base excision repair (B...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2025-09-01
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| Colecção: | Clinical Epigenetics |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13148-025-01978-x |
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