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Asparaginase-specific basophil recognition and activation predict Asparaginase hypersensitivity in mice

BackgroundAsparaginase (ASNase) is a crucial part of acute leukemia treatment, but immune responses to the agent can reduce its effectiveness and increase the risk of relapse. Currently, no reliable and validated biomarker predicts ASNase-induced hypersensitivity reactions during therapy. We aimed t...

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Hlavní autoři: Sanjay Rathod, Keito Hoshitsuki, Yin Zhu, Manda Ramsey, Christian A. Fernandez
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2024-04-01
Edice:Frontiers in Immunology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1392099/full
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