SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

ABSTRACT Cyclic GMP-AMP synthase (cGAS) is an important DNA pattern recognition receptor that senses double-stranded DNA derived from invading pathogens or self DNA in cytoplasm, leading to an antiviral interferon response. A tick-borne Bunyavirus, severe fever with thrombocytopenia syndrome virus (...

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Detalhes bibliográficos

Principais autores:	Ze-zheng Jiang, Min Chu, Li-na Yan, Wen-kang Zhang, Bang Li, Jiao Xu, Zhong-xin Zhao, Hui-Ju Han, Chuan-min Zhou, Xue-jie Yu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-06-01
coleção:	Microbiology Spectrum
Assuntos:	cGAS innate immunity nucleoprotein SFTSV RNA virus autophagy
Acesso em linha:	https://journals.asm.org/doi/10.1128/spectrum.03796-23
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