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Exiting the ground state: the broad spectrum of cell fates accessible from naïve human pluripotent stem cells

Abstract Naïve human pluripotent stem cells (hPSCs) represent an in vitro analog of the pre-implantation epiblast – the founder tissue of the embryo proper. A widely held assumption, based on prior studies in the mouse system, was that naïve hPSCs are restricted in their differentiation potential to...

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Hlavní autoři: Kyoung-mi Park, Richard Yin, Thorold W. Theunissen
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer 2026-01-01
Edice:Cellular and Molecular Life Sciences
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On-line přístup:https://doi.org/10.1007/s00018-025-05984-3
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