An in vitro co-culture mouse model demonstrates efficient vaccine-mediated control of Francisella tularensis SCHU S4 and identifies nitric oxide as a predictor of efficacy

Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a c...

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Detalhes bibliográficos

Principais autores:	Igor Golovlev, Helena Lindgren, Kjell Eneslätt, Wayne Conlan, Amandine Mosnier, Thomas Henry, Anders Sjöstedt
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2016-11-01
Colecção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	Nitric Oxide correlates of protection F. tularensis SCHU S4 in vitro co-culture model mouse immune response
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00152/full
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