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PARP inhibitors as radiosensitizers: a comprehensive review of preclinical evidence and clinical applications

Poly (ADP ribose) polymerase 1 (PARP1) plays a central role in the response of DNA damage induced by tumor radiotherapy. This paper systematically reviewed the structural and functional characteristics of PARP1 and its molecular mechanism in DNA damage repair, and focused on the preclinical evidence...

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Hoofdauteurs: Xiaodong Luo, Shuo Gao, Kaiyang Sun, Zhiqiang Dong, Shude Yang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2025-11-01
Reeks:Frontiers in Oncology
Onderwerpen:
PARP1
radiotherapy
DNA damage repair
PARP inhibitors
radiosensitization
synthetic lethality
Online toegang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1702121/full
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