Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Abstract Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates in cardiomyocytes, but the cellular...

Descripció completa

Dades bibliogràfiques

Autors principals:	Marion Bouvet, Emilie Dubois-Deruy, Annie Turkieh, Paul Mulder, Victoriane Peugnet, Maggy Chwastyniak, Olivia Beseme, Arthur Dechaumes, Philippe Amouyel, Vincent Richard, Nicolas Lamblin, Florence Pinet
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2021-06-01
Col·lecció:	Cell Death Discovery
Accés en línia:	https://doi.org/10.1038/s41420-021-00549-2
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!