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Single‐cell and repertoire profiling reveals immune remodelling in paediatric upper airway: insights from adenoid hypertrophy

Abstract Objectives To characterise the immune cellular landscape and paired B‐cell and T‐cell receptor repertoires of hypertrophic adenoids in children with obstructive sleep apnoea. Methods We performed 10x Genomics 5′ single‐cell RNA sequencing with paired V(D)J profiling on adenoid tissues from...

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Principais autores: Chao Wang, Yufei Pan, Xiao Han, Kai Sun, Jing Li, Yuanyuan Lu, Zhenkun Yu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-06-01
Serier:Clinical & Translational Immunology
Fag:
adenoid hypertrophy
children
immune repertoire
obstructive sleep apnoea
single‐cell RNA sequencing
Online adgang:https://doi.org/10.1002/cti2.70101
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