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Dally is not essential for Dpp spreading or internalization but for Dpp stability by antagonizing Tkv-mediated Dpp internalization

Dpp/BMP acts as a morphogen to provide positional information in the Drosophila wing disc. Key cell-surface molecules to control Dpp morphogen gradient formation and signaling are heparan sulfate proteoglycans (HSPGs). In the wing disc, two HSPGs, the glypicans Division abnormally delayed (Dally) an...

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Principais autores: Niklas Simon, Abu Safyan, George Pyrowolakis, Shinya Matsuda
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-01-01
Serier:eLife
Fag:
morphogen
Dpp/BMP
glypican
Dally
wing disc
Online adgang:https://elifesciences.org/articles/86663
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