Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Abstract Background The receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain (FLT3-ITD) is a poor prognostic factor; however, the prognostic significance of missense mutation in the tyrosine kinase domain (FLT3-TKD) is controversial. Furthermore, the accomp...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Wei Guan, Lei Zhou, Yan Li, Erna Yang, Yangyang Liu, Na Lv, Lin Fu, Yi Ding, Nan Wang, Nan Fang, Qian Liu, Binan Wang, Fuwei Li, Juan Zhang, Maoquan Wang, Lili Wang, Yu Jing, Yonghui Li, Li Yu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2021-04-01
Цуврал:	Experimental Hematology & Oncology
Нөхцлүүд:	Acute myeloid leukemia FLT3-ITD FLT3-TKD TET2 Next-generation sequencing
Онлайн хандалт:	https://doi.org/10.1186/s40164-021-00207-4
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!