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Network pharmacology- and cell-based assessments identify the FAK/Src pathway as a molecular target for the antimetastatic effect of momordin Ic against cholangiocarcinoma

Previous studies have indicated the efficacy of momordin Ic (MIc), a plant-derived triterpenoid, against several types of cancers, implying its potential for further development. However, comprehensive insights into the molecular mechanisms and targets of MIc in cholangiocarcinoma (CCA) are lacking....

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Principais autores: Piman Pocasap, Auemduan Prawan, Sarinya Kongpetch, Laddawan Senggunprai
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-06-01
Serier:Heliyon
Fag:
Momordin Ic
Cholangiocarcinoma
Network pharmacology
Antimetastasis
FAK
Src
Online adgang:http://www.sciencedirect.com/science/article/pii/S240584402408383X
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