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Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

Abstract Background To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkop...

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Autores principales: Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2018-03-01
Colección:BMC Oral Health
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Acceso en línea:http://link.springer.com/article/10.1186/s12903-018-0492-8
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