New 1,2,4-Triazole Potential Inhibitors of Mycobacterial Imidazoleglycerol-Phosphate Dehydratase (IGPD)

A number of new 5-aminomethyl-1,2,4-triazole-3-carboxamides, demonstrating high model affinity to the IGPD catalytic site comparable with that of the native substrate, were synthesized. The derivatives obtained were tested for antimicrobial potential against <i>M. smegmatis</i>, a species related to...

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Hlavní autoři:	Eugenia Oleynik, Ekaterina Pyankina, Ekaterina Mitina, Ekaterina Mikhina, Andrey Matveev
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2024-11-01
Edice:	Chemistry Proceedings
Témata:	5-aminomethyl-1,2,4-triazole-3-carboxamides imidazoleglycerol-phosphate dehydratase IGPD inhibitors anti-tuberculosis agents
On-line přístup:	https://www.mdpi.com/2673-4583/16/1/67
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