Sirt1 overexpression attenuates Western‐style diet‐induced aortic stiffening in mice

Abstract Increased arterial stiffness is a cardiovascular disease risk factor in the setting of advancing age and Western diet (WD) induced obesity. Increases in large artery stiffness, as measured by pulse wave velocity (PWV), occur within 8 weeks of WD feeding in mice. Sirtuin‐1 (Sirt1), a NAD‐dep...

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Autors principals:	Venkateswara R. Gogulamudi, Daniel R. Machin, Grant D. Henson, Jisok Lim, Richard C. Bramwell, Jessica R. Durrant, Anthony J. Donato, Lisa A. Lesniewski
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2022-05-01
Col·lecció:	Physiological Reports
Matèries:	aorta arterial stiffness Sirt1 sirtuins Western diet
Accés en línia:	https://doi.org/10.14814/phy2.15284
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