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Methodological biases in observational hospital studies of COVID-19 treatment effectiveness: pitfalls and potential

IntroductionThis study aims to discuss and assess the impact of three prevalent methodological biases: competing risks, immortal-time bias, and confounding bias in real-world observational studies evaluating treatment effectiveness. We use a demonstrative observational data example of COVID-19 patie...

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Principais autores: Oksana Martinuka, Derek Hazard, Hamid Reza Marateb, Marjan Mansourian, Miguel Ángel Mañanas, Sergio Romero, Manuel Rubio-Rivas, Martin Wolkewitz
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-03-01
coleção:Frontiers in Medicine
Assuntos:
competing risks
confounding
COVID-19
emulated trial
immortal-time bias
methodological bias
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmed.2024.1362192/full
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