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Clinical Trials of the BTK Inhibitors Ibrutinib and Acalabrutinib in Human Diseases Beyond B Cell Malignancies

The BTK inhibitors ibrutinib and acalabrutinib are FDA-approved drugs for the treatment of B cell malignances. Both drugs have demonstrated clinical efficacy and safety profiles superior to chemoimmunotherapy regimens in patients with chronic lymphocytic leukemia. Mounting preclinical and clinical e...

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Principais autores: Sining Zhu, Jaeyong Jung, Eton Victor, Johann Arceo, Samantha Gokhale, Ping Xie
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-10-01
Serier:Frontiers in Oncology
Fag:
BTK
ibrutinib
acalabrutinib
immunomodulation
immune responses
inflammation
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2021.737943/full
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