Antifungal conjugates incorporating N 5-acetyl-N 5-hydroxy-l-ornithine as a molecular carrier

Abstract A simplified, artificial siderophore, N 5-acetyl-N 5-hydroxy-l-ornithine (AHO), can be used as a molecular carrier for the construction of the Trojan Horse-type conjugates exhibiting antifungal activity. Rationally designed AHO-incorporating conjugates with 4-cyano-tryptophan were effective...

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Principais autores:	Joanna Stefaniak-Skorupa, Natalia Maciejewska, Hira Zahoor Rajput, Andrzej S. Skwarecki, Piotr Szweda, Sławomir Milewski, Maria J. Milewska
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2026-04-01
Serija:	Scientific Reports
Teme:	Antifungal conjugates Hydroxamate siderophore Trojan Horse strategy Trimethyl lock
Online dostop:	https://doi.org/10.1038/s41598-026-50833-3
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