ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction

Abstract Myocardial infarction (MI) compromises the cardiac microvascular endothelial barrier, increasing leakage and inflammation. HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during MI. Here, we show that inducible, adult endo...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Karim Ullah, Lizhuo Ai, Yan Li, Lifeng Liu, Qin Zhang, Kaichao Pan, Zainab Humayun, Lin Piao, Albert Sitikov, Qiong Zhao, Qiaozhu Su, Willard Sharp, Yun Fang, David Wu, James K. Liao, Rongxue Wu
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2025-03-01
Rangatū:	Communications Biology
Urunga tuihono:	https://doi.org/10.1038/s42003-025-07753-1
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!