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Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone Resorption in vivo Through GPR120 by Inhibiting TNF-α Production in Macrophages and Directly Inhibiting Osteoclast Formation

Docosahexaenoic acid (DHA) is an n-3 fatty acid that is an important structural component of the cell membrane. DHA exerts potent anti-inflammatory effects through G protein-coupled receptor 120 (GPR120), which is a functional receptor for n-3 fatty acids. DHA also regulates osteoclast formation and...

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Autori principali: Akiko Kishikawa, Hideki Kitaura, Keisuke Kimura, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Fumitoshi Ohori, Takahiro Noguchi, Aseel Marahleh, Yasuhiko Nara, Atsuhiko Ichimura, Itaru Mizoguchi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019-03-01
Serie:Frontiers in Endocrinology
Soggetti:
osteoclast
DHA
LPS
mouse
GPR120
Accesso online:https://www.frontiersin.org/article/10.3389/fendo.2019.00157/full
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