A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila.

Hedgehog (Hh) proteins are secreted molecules that function as organizers in animal development. In addition to being palmitoylated, Hh is the only metazoan protein known to possess a covalently-linked cholesterol moiety. The absence of either modification severely disrupts the organization of numer...

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Библиографические подробности

Главные авторы:	Reid Aikin, Alexandra Cervantes, Gisela D'Angelo, Laurent Ruel, Sandra Lacas-Gervais, Sébastien Schaub, Pascal Thérond
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2012-01-01
Серии:	PLoS ONE
Online-ссылка:	http://europepmc.org/articles/PMC3303847?pdf=render
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