Hepatic stellate cell derived lipid droplets drive protumoral M2 macrophage polarization in hepatocellular carcinoma

Abstract Background During chronic liver injury, hepatic stellate cells (HSCs) lose their vitamin-A–rich lipid droplets (LDs), yet whether these organelles are merely degraded or released via vesicles and functionally relevant remains unclear. We investigated the fate of HSCs LDs and their impact on...

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Bibliografiske detaljer

Principais autores:	Yundan You, Sha Huang, Jingjie Xu, Qifei Li, Yu Wang, Zhouwei Zhan, Yong Ye, Bin Lan, Xuefeng Wang, Zengqing Guo, Qiaoting Hu
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2026-02-01
Serier:	Discover Oncology
Fag:	Hepatocellular carcinoma Tumor microenvironment Hepatic stellate cell Tumor-Associated macrophage Lipid droplet Metabolic reprogramming.
Online adgang:	https://doi.org/10.1007/s12672-026-04626-9
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