Rho-Associated Kinase Inhibitor Fasudil Protects from Sepsis-Induced Acute Kidney Injury in Rat via Suppressing STAT-3 and NLRP-3 Pathway

Sepsis-associated acute kidney injury (S-AKI) is a severe complication in critically ill patients, marked by inflammation, oxidative stress, and renal dysfunction. This study aimed to evaluate the renoprotective effects of Fasudil (Fas), a Rho-associated kinase inhibitor, in a rat model of S-AKI ind...

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Bibliografische gegevens

Hoofdauteurs:	Neslihan Şahin, Ejder Saylav Bora, Osman Sezer Çınaroğlu, Oytun Erbaş
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2025-05-01
Reeks:	Current Issues in Molecular Biology
Onderwerpen:	sepsis-associated acute kidney injury Fasudil STAT-3 pathway NLRP-3 inflammasome Rho kinase inhibitor
Online toegang:	https://www.mdpi.com/1467-3045/47/5/340
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