Identifying pathways regulating the oncogenic p53 family member ΔNp63 provides therapeutic avenues for squamous cell carcinoma

Abstract Background ΔNp63 overexpression is a common event in squamous cell carcinoma (SCC) that contributes to tumorigenesis, making ΔNp63 a potential target for therapy. Methods We created inducible TP63-shRNA cells to study the effects of p63-depletion in SCC cell lines and non-malignant HaCaT ke...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Zuzana Pokorna, Jan Vyslouzil, Borivoj Vojtesek, Philip J. Coates
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2022-02-01
Цуврал:	Cellular & Molecular Biology Letters
Нөхцлүүд:	ΔNp63 Oncogene addiction Squamous cell carcinoma DNA damage Histone deacetylase inhibitors Growth factor signaling
Онлайн хандалт:	https://doi.org/10.1186/s11658-022-00323-x
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!