Effect of preoperative intranasal insulin on postoperative delirium in adult surgical patients: a systematic review, meta-analysis, and trial sequential analysis

Abstract Background Postoperative delirium (POD) is a frequent and serious complication, especially in older adults and high-risk surgical patients. Intranasal insulin has emerged as a potential neuroprotective intervention, possibly modulating neuroinflammation and preserving cognitive function. Th...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Emmanuel Mark M. Velasco, Vinicius Sepúlveda Lima, Tulio Caldonazo, Felipe S. Passos, Paulo Ricardo Gessolo Lins, Iago Teles Costa Grillo, Pedro Tanaka, Alex Macario, Aleksandar R. Zivkovic, João da ManoelSilva, Johannes Ehler, Ricardo Esper Treml
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2026-03-01
Σειρά:	Perioperative Medicine
Θέματα:	Intranasal insulin Postoperative delirium Neuroinflammation Perioperative neuroprotection
Διαθέσιμο Online:	https://doi.org/10.1186/s13741-026-00674-5
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