Differential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy

Orexin neuropeptides influence multiple homeostatic functions and play an essential role in the expression of normal sleep-wake behavior. While their two known receptors (OX1 and OX2) are targets for novel pharmacotherapeutics, the actions mediated by each receptor remain largely unexplored. Using b...

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Autors principals:	Kristi A Kohlmeier, Christopher J Tyler, Mike eKalogiannis, Masaru eIshibashi, Morten P Kristensen, Iryna eGumenchuk, Richard M Chemelli, Yaz eKisanuki, Masashi eYanagisawa, Christopher S Leonard
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2013-12-01
Col·lecció:	Frontiers in Neuroscience
Matèries:	Locus Coeruleus dorsal raphe nucleus Ca2+ signaling whole-cell patch-clamp recording laterodorsal tegmental nucleus
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00246/full
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