METTL3 promotes podocyte pyroptosis in diabetic nephropathy through N6-methyladenosine modification of TRIM29 mRNA

Multiple studies have revealed the critical roles of epigenetic modifications in the development of diabetic nephropathy (DN). Methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m6A) RNA modification in podocytes represents a new disease mechanism in DN. The tripartite motif-containing (...

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Autors principals: Xiaohong Xu, Xiaolin Huang, Ce Zhang, Xia Mi, Chi Zhang, Fei Hua, Liexiang Zhang
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2025-12-01
Col·lecció:Renal Failure
Matèries:
Diabetic nephropathy
METTL3
TRIM29
YTHDF1
NLRP3 inflammasome
pyroptosis
Accés en línia:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2497492
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